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Ivermectin is typically given as one or two oral doses. Ivermectin therapy has been associated with minor, self-limiting serum aminotransferase elevations and very rare instances of clinically apparent liver injury Ivermectin is used to treat strongyloidiasis threadworm; infection with a type of roundworm that enters the body through the skin, moves through the airways and lives in the intestines.
Ivermectin is also used to control onchocerciasis river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness.
Ivermectin is in a class of medications called anthelmintics. It treats strongyloidosis by killing the worms in the intestines.
Ivermectin treats onchocerciasis by killing the developing worms. Ivermectin does not kill the adult worms that cause onchocerciasis and therefore it will not cure this type of infection.
Ivermectin is also sometimes used to treat certain other roundworm infections, head or pubic lice infestation, and scabies itchy skin condition caused by infestation with small mites that live under the skin.
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Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivermectin exactly as directed.
Do not take more or less of it or take it more often than prescribed by your doctor. Retreatment is required because ivermectin has no activity against adult onchocerca volvulus parasites which tend to reside in subcutaneous nodules.
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Safety and efficacy have not been established. Pregnancy Category C: Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.
Breastfeeding: There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Ivermectin is excreted into human milk in low concentrations.
The manufacturer recommends that treatment during nursing only occur if the risk of delayed treatment to the mother outweighs the possible risk to the infant.
Weigh the potential benefits against the potential risks before taking this medication while breastfeeding. Allergic and inflammatory reactions the Mazzotti reaction may occur with ivermectin, probably due to the death of the microfilariae.
Patients treated with ivermectin therapy for onchocerciasis may experience these reactions in addition to clinical adverse reactions possibly, probably, or definitely related to the therapy itself.
The treatment of severe Mazzotti reactions has not been subjected to controlled clinical studies. After treatment with microfilaricidal medications, patients with hyperreactive onchodermatitis sowda may be more likely than others to experience severe adverse reactions, especially edema and aggravation of onchodermatitis.
Serious or fatal encephalopathy has been reported rarely in patients with onchocerciasis, and heavily infected with Loa loa, either spontaneously or after treatment with ivermectin.
This syndrome has been seen very rarely following the use of ivermectin therapy. Pretreatment assessment for loiasis and careful posttreatment follow-up should be implemented in all patients considered for treatment with ivermectin for any reason and who had exposure to Loa loa endemic areas of West and Central Africa.
The patient should be advised of the need for repeated stool examinations to document clearance of infection with Strongyloides stercoralis.
The patient should be advised that treatment with ivermectin does not kill the adult Onchocerca parasites, and therefore repeated follow-up and retreatment is usually necessary.
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